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CHARLESTOWN, Mass., Dec. 23, 2024 (GLOBE NEWSWIRE) -- Solid Biosciences Inc. (Nasdaq: SLDB) (the “Company” or “Solid”), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today announced that it was added to the Nasdaq Biotechnology Index ® (Nasdaq: NBI) effective prior to the market open on Monday, December 23, 2024. The Nasdaq Biotechnology Index is designed to track the performance of a set of securities listed on The Nasdaq Stock Market ® (Nasdaq ® ) that are classified as either biotechnology or pharmaceutical according to the Industry Classification Benchmark (ICB). The NBI is calculated under a modified capitalization-weighted methodology. Companies in the NBI must meet eligibility requirements, including minimum market capitalization, average daily trading volume, and seasoning as a public company, among other criteria. Nasdaq selects constituents once annually in December. For more information about the Nasdaq Biotechnology Index, please visit https://indexes.nasdaqomx.com/Index/Overview/NBI . About Solid Biosciences Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates including SGT-003 for the treatment of Duchenne muscular dystrophy (Duchenne), SGT-501 for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), SGT-601 for the treatment of TNNT2-mediated dilated cardiomyopathy, SGT-401 for the treatment of BAG3-mediated dilated cardiomyopathy, and additional assets for the treatment of fatal cardiac diseases. Solid is advancing its diverse pipeline across rare neuromuscular and cardiac diseases, bringing together experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted, Solid’s mandate is to improve the daily lives of patients living with these devastating diseases. For more information, please visit www.solidbio.com . Solid Biosciences Investor Contact: Nicole Anderson Director, Investor Relations and Corporate Communications Solid Biosciences Inc. investors@solidbio.com Media Contact: Glenn Silver FINN Partners glenn.silver@finnpartners.com
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The injunction, which the Court said it will enter in January 2025 , is expected to prohibit Bruker from making, using, selling or offering to sell in the United States its GeoMx Digital Spatial Profiler and associated instruments, reagents and services for RNA and protein detection. At the request of 10x Genomics, the injunction will not block ongoing research by researchers who installed a GeoMx instrument prior to November 18, 2023 . Such customers can continue to purchase GeoMx reagents for use with existing GeoMx instruments for purposes of continuing their ongoing research. The Court found that making such an exception for ongoing research strikes a "workable balance between protecting the patentee's rights and protecting the public from the injunction's adverse effects." In addition, the Court affirmed the $31 million damages awarded by the November 2023 jury verdict, as well as supplemental damages and interest that will be added to the total damages when final judgment is entered. "Today's decision helps to safeguard our decade-long investment in innovation and ensures we can continue to develop groundbreaking technologies that help our customers revolutionize science," said Eric Whitaker , Chief Legal Officer at 10x Genomics. "10x exists to fuel scientific progress – not stifle it – and that is why we've done our utmost to ensure this injunction was structured to protect both our intellectual property and existing GeoMx customers' ongoing research." The Court recognized the harm NanoString's infringing conduct caused 10x when it wrote in its ruling, "Having been careful not to license its technology, 10x suffers when it proclaims itself as an innovator in spatial genomics but a competitor is using the same innovative, patented technology." Today's Court decision follows a November 2023 jury verdict that found that NanoString's GeoMx products willfully infringed seven patents exclusively licensed to 10x Genomics by Prognosys. During the trial, the jury heard testimony from the sole inventor of the patents, Illumina co-founder Mark Chee , and NanoString CEO Brad Gray and NanoString CSO Joe Beechem. After hearing all of the evidence, the jury determined that all seven patents had been infringed by NanoString, that each patent was valid, that NanoString willfully infringed those patents and that monetary damages were owed to 10x for the infringement of all seven patents. In affirming the jury's finding that NanoString willfully infringed, the Court relied on the evidence showing that NanoString knew or was willfully blind that its acts would cause infringement of 10x's rights. The asserted patents in Case No. 21-cv-653-MFK include (a) U.S. Patent No. 10,472,669; (b) U.S. Patent No. 10,961,566; (c) U.S. Patent No. 10,983,113; (d) U.S. Patent No. 10,996,219; (e) U.S. Patent No. 11,001,878; (f) U.S. Patent No. 11,008,607 and (g) U.S. Patent No. 11,293,917. About 10x Genomics 10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn or X (Twitter) . Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the "safe harbor" created by those sections. All statements included in this press release, other than statements of historical facts, may be forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as "may," "might," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "contemplate," "believe," "see," "estimate," "predict," "potential," "would," "likely," "seek" or "continue" or the negatives of these terms or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include statements regarding litigation and remedies as well as possible outcomes of litigation. These forward-looking statements do not reflect that our success will depend on our ability to obtain, maintain and protect our intellectual property rights, intellectual property litigation could be expensive, time-consuming, unsuccessful and could interfere with our ability to develop, manufacture and commercialize our products or technologies, litigation outcomes are unpredictable or there may be changes in our litigation strategy. These statements are based on management's current expectations, forecasts, beliefs, assumptions and information currently available to management. Actual outcomes and results could differ materially from these statements due to a number of factors and such statements should not be relied upon as representing 10x Genomics, Inc.'s views as of any date subsequent to the date of this press release. 10x Genomics, Inc. disclaims any obligation to update any forward-looking statements provided to reflect any change in 10x Genomics' expectations or any change in events, conditions or circumstances on which any such statement is based, except as required by law. The material risks and uncertainties that could affect 10x Genomics, Inc.'s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in the company's most recently-filed 10-K for the fiscal year ended December 31, 2023 and elsewhere in the documents 10x Genomics, Inc. files with the Securities and Exchange Commission from time to time. Disclosure Information 10x Genomics uses filings with the Securities and Exchange Commission, our website ( www.10xgenomics.com ), press releases, public conference calls, public webcasts and our social media accounts as means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD. Contacts Investors: investors@10xgenomics.com Media: media@10xgenomics.com View original content to download multimedia: https://www.prnewswire.com/news-releases/us-district-court-awards-10x-genomics-permanent-injunction-in-patent-infringement-lawsuit-against-bruker-corporations-geomx-products-302338627.html SOURCE 10x Genomics, Inc.Kurtis Rourke has made the Jon Cornish Trophy a family affair. The Indiana quarterback received the award Monday, which is presented annually to the top Canadian playing football in the NCAA. Rourke’s older brother, Nathan, currently with the CFL’s B.C. Lions, won the award twice in 2017 and 2018 at Ohio. “It’s awesome,” Rourke said. “Kind of getting introduced to the Jon Cornish Trophy back when Nathan won it a couple of times, I wanted to be able to have a shot and it was one of my goals to be in the conversation, be in the running. “It just means a ton to be recognized just because Canadian athletes don’t get recognized too often. I’m just so glad we’re able to get that recognition and continue to do it for our country.” Rourke finished first in voting ahead of Montreal’s Dariel Djabome, a junior linebacker at Rutgers. Stanford receiver Elic Ayomanor, last year’s winner, was third, followed by Vancouver’s Ty Benefield (sophomore safety, Boise State) and Jett Elad of Mississauga, Ont., a senior safety at UNLV. Cornish, of New Westminster, B.C., was a standout running back at Kansas who went on to have a decorated CFL career with the Calgary Stampeders (2007-15) before being inducted into the Canadian Football Hall of Fame in 2019. Rourke transferred to Indiana last December to boost his NFL draft stock after five years at Ohio, where he began as a backup to his older brother. The junior Rourke then captured the ‘22 MAC offensive player of the year award despite suffering a season-ending knee injury before heading to Indiana after the 2023 season. Rourke was instrumental in Indiana — traditionally known as a basketball school — emerging as a Big Ten contender in head coach Curt Cignetti’s first season. After winning 11 of their first 12 games, the Hoosiers’ stellar campaign ended with a 27-17 loss to Notre Dame in the opening game of the expanded U.S. college football playoff bracket. Rourke finished 20-of-33 passing for 215 yards with two touchdowns and an interception in that contest. Overall, Rourke completed 222 of 320 passes (69.4 per cent) for 3,042 yards with 29 TDs and five interceptions. “What a privilege, opportunity to come join a program that had so much to prove,” Rourke said. “It kind of aligned with what I was wanting to do, which was prove I could play at a higher level.” The six-foot-five, 223-pound Rourke was named a finalist for the Manning Award, presented annually to the NCAA’s top quarterback. He was also ninth in voting for the Heisman Trophy as U.S. college football’s outstanding player. “College football has been everything to me,” Rourke said. “Starting off my freshman year to be able to watch Nathan grow and play in his senior year and just learn from him in both how to live a college life but also be a college quarterback as well. “I won’t forget my time at Ohio at all, it really created me and moulded me into the person, player I am. I’m extremely grateful for the entire college football experience.” The former Holy Trinity star becomes just the second Canadian high school graduate to claim the Jon Cornish Trophy. Chuba Hubbard, of Sherwood Park, Alta., and currently with the NFL’s Carolina Panthers, did so in 2019 while at Oklahoma State. The six-foot-two, 240-pound Djabome recorded 102 tackles (48 solo), three sacks and two forced fumbles this season. Rutgers faces Kansas State in the Rate Bowl on Boxing Day. The six-foot-two, 210-pound Ayomanor, a redshirt junior, was one of the few bright spots this season for Stanford (3-9). He registered 63 catches for 831 yards and six TDs after recording 62 receptions for 1,013 yards and six touchdowns in 2023. Last week, Ayomanor declared for the ‘25 NFL draft. The six-foot-two, 204-pound Benefield led Boise State in tackles (73), solo tackles (53) and interceptions (two) while also registering five tackles for a loss, a forced fumble and two recoveries. The Broncos are the third seed in U.S. college football’s expanded playoffs and face Penn State in the Fiesta Bowl on Dec. 31. Elad registered 55 tackles, an interception and six pass knockdowns during the regular season. He added 12 tackles (nine solo) and a sack in the Runnin’ Rebels’ 24-13 win over Cal in the Art of Sport LA Bowl to finish with an 11-3 overall record.Scottie Scheffler has new putting grip and trails Cameron Young by 3 in Bahamas
U.S. District Court Awards 10x Genomics Permanent Injunction in Patent Infringement Lawsuit Against Bruker Corporation's GeoMx ProductsWhen Supreme Court justices debated Tennessee’s ban on gender-affirming care yesterday, they kept calling the science “evolving” and “uncertain. ” Last year, Tennessee made it illegal for doctors to provide gender-affirming care to trans teens. Their reason? The state claims it needs to make sure young people don’t become “disdainful of their sex” — that’s the actual language in the law. That’s not how medicine works, doctors say. “When we ban care or slow down care, we’re affecting an entire age cohort and putting them at risk for worse mental health,” says Dr. Carl Streed Jr., who leads the World Professional Association for Transgender Health’s U.S. chapter and runs research at Boston Medical Center’s GenderCare Center, told USA Today . The state’s case leans heavily on claims about medical uncertainty. But Dr. Joshua Safer, who heads Mount Sinai’s transgender medicine center in New York, also told USA Today the approach for treating trans youth is already “conservative” and carefully individualized. “We try to be thoughtful and conservative when we support parents and kids,” he said. What Tennessee’s law actually does is block doctors from using the same medications for trans kids that they can freely prescribe to other youth for different conditions. It’s this bizarre contradiction that’s now before the Supreme Court. Major medical organizations filed receipts with the Court in the form of amicus briefs. The American Academy of Pediatrics brought the data : Studies show that access to puberty blockers and hormone therapy, when prescribed according to established guidelines, significantly reduces mental health crises for trans youth who need them. But Tennessee’s case relies heavily on six doctors—and that’s where things get sketchy. A recent investigation by Accountable.US found that courts have repeatedly called out four of these experts for: These are the basic facts that got buried in court: While Justice Roberts called this an “evolving situation,” medical groups say the basic science is solid. What’s actually evolving is the political fight—25 states have passed similar bans despite major medical associations opposing them. RECOMMENDED • silive .com Popular ‘90s band cancels upcoming shows after singer ends up in hospital Dec. 5, 2024, 12:47 p.m. Dear Abby: I just found out my fiance is secretly bisexual or gay Dec. 4, 2024, 6:00 a.m. The American Medical Association’s position is clear: “Trans and non-binary gender identities are normal variations of human identity and expression.” They warn that blocking care access can have “tragic health consequences.” The Court will rule by June. At stake isn’t just Tennessee’s law— similar bans in 25 other states could be affected. For trans teens and their doctors caught in the middle, the wait continues.
Stocks shook off a choppy start to finish higher Monday, as Wall Street kicked off a holiday-shortened week. The S&P 500 ended 0.7% higher after having been down 0.5% in the early going. The Dow Jones Industrial Average also recovered from an early slide to eke out a 0.2% gain. The tech-heavy Nasdaq composite rose 1%. Gains in technology and communications stocks accounted for much of the gains, outweighing losses in consumer goods companies and elsewhere in the market. Semiconductor giant Nvidia, whose enormous valuation gives it an outsize influence on indexes, rose 3.7%. Broadcom climbed 5.5% to also help support the broader market. Walmart fell 2% and PepsiCo slid 1%. Japanese automakers Honda and Nissan said they are talking about combining in a deal that might also include Mitsubishi Motors. U.S.-listed shares in Honda jumped 12.7%, while Nissan ended flat. Eli Lilly rose 3.7% after announcing that regulators approved Zepbound as the first and only prescription medicine for adults with sleep apnea. Department store Nordstrom fell 1.5% after it agreed to be taken private by Nordstrom family members and a Mexican retail group in a $6.25 billion deal. All told, the S&P 500 rose 43.22 points to 5,974.07. The Dow gained 66.69 points to 42,906.95. The Nasdaq rose 192.29 points to 19,764.89. Traders got a look at a new snapshot of U.S. consumer confidence Monday. The Conference Board said that consumer confidence slipped in December. Its consumer confidence index fell back to 104.7 from 112.8 in November. Wall Street was expecting a reading of 113.8. The unexpectedly weak consumer confidence update follows several generally strong economic reports last week. One report showed the overall economy grew at a 3.1% annualized rate during the summer, faster than earlier thought. The latest report on unemployment benefit applications showed that the job market remains solid. A report on Friday said a measure of inflation the Federal Reserve likes to use was slightly lower last month than economists expected. Worries about inflation edging higher again had been weighing on Wall Street and the Fed. The central bank just delivered its third cut to interest rates this year, but inflation has been hovering stubbornly above its target of 2%. It has signaled that it could deliver fewer cuts to interest rates next year than it earlier anticipated because of concerns over inflation. Expectations for more interest rate cuts have helped drive a roughly 25% gain for the S&P 500 in 2024. That drive included 57 all-time highs this year. Inflation concerns have added to uncertainties heading into 2025, which include the labor market's path ahead and shifting economic policies under an incoming President Donald Trump. "Put simply, much of the strong market performance prior to last week was driven by expectations that a best-case scenario was the base case for 2025," said Brent Schutte, chief investment officer at Northwestern Mutual Wealth Management Company Treasury yields rose in the bond market. The yield on the 10-year Treasury rose to 4.59% from 4.53% late Friday. European markets closed mostly lower, while markets in Asia gained ground. Wall Street has several other economic reports to look forward to this week. On Tuesday, the U.S. will release its November report for sales of newly constructed homes. A weekly update on unemployment benefits is expected on Thursday. Markets in the U.S. will close at 1 p.m. Eastern on Tuesday for Christmas Eve and will remain closed on Wednesday for Christmas.
Thank you for your feedback on our plan for a front page refresh. I was cheered (and a little surprised) by the largely positive reception. I’ll try to capture the range of views here in a balanced way, though, from “love it” to “mess”. Quick recap: We have plans to update our masthead to 1) reflect what people actually call us ( The i / The i Paper ), 2) build recognition among existing readers and a new generation discovering our journalism, 3) include a strapline with our commitment to “impartial news and intelligent debate”, 4) update our logo, to make us easier to recognise out of context. (Away from our print front page, “ The i Paper ” is clearer than an isolated letter “ i ” on its own.) We know you are open-minded and highly engaged with this newspaper you care about so much. I’ll start with a few positive reactions then move on to critical views. “Clever, effective and succinct,” writes Diana Hunt. “Modern and appealing,” adds Rose McCray, who asks about the typeface, which reminds her of The New York Times . (I’ll take that.) The font is a serif, Larken, noted for its “natural softness and expressiveness”, and will feature in our iweekend edition. More about that on Saturday. “For what my opinion is worth,” adds Shirley Johnson from Linton Colliery, Northumberland, “I really like the newly-styled ‘ i ’. Lower-case and somehow look like a person! And I love that you refer to yourselves as The i Paper , which is what I call you.” She adds: “I hope you don’t abandon the bullet points below the main headline.” Fear not, Shirley: the rest of our front page design remains the same. A prominent red masthead still features in the top left corner for easy recognition, alongside our familiar layout. Bristol’s Karen Sadler isn’t a fan. “Muddled and inelegant” is her verdict – she prefers the existing. Chelmsford’s Peter Adkins is open to change but calls the mocked-up layout “appalling”. He adds: “Other than that, keep up the good work.” Read Next The best new books to read in September, from Zadie Smith’s The Fraud to the new Richard Osman Gill Roche dislikes the use of “ paper ”, asking with consternation: “What else could it be – Richard Osman’s latest book?” Gill, I confess that was also my starting point. I was won over by its versatility in different settings – crucial so that people recognise our (trusted) journalism in a rather noisy environment, whether they come into contact with it in print , online, on other media like TV, or word of mouth. Plymouth’s Richard Haighton says “ The i ”, but adds: “Always great to move on” – which sort of sums up the mindset of our readers over the past 14 years. Dave Beck likes the “modern” look. He wonders whether we might find a way to abbreviate it within articles, perhaps with an updated glyph (icon). I’ll speak to the Production team, Dave. Good to hear from so many regulars, as well as new readers. Subscriber Mike Newman, who writes to me periodically from Shefford, Beds, to keep me vigilant about the political balance of our columnists, sends encouragement: “Congratulations on the revamp. Love the ‘ i ’ logo.” We publish a selection of letters (critical and positive) on page 24 today, and we welcome reader feedback. You can reach me on i@inews.co.uk or @olyduf f on social media.A few questions about veggies
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Oshkosh Corporation Names Matthew Field as Chief Financial OfficerShoplifting is a growing blight on brick-and-mortar retailers globally and across the state, and San Francisco’s stores are no exception. Brazen criminals feel they can shoplift by day or break-and-enter at night, typically without fear of arrest or reprisals. The closure of Bayside Market is a notable recent example , but there are many more, and with stores operating on knife-edge margins, competing against online stores with few such concerns, the next theft could be the last. With little help from over-stretched police, despite a recent 911 response center $9 million renovation , and unresponsive politicians, stores have to take their own preventative steps. Larceny rates, which includes shoplifting, have been on the rise for years in San Francisco, despite a recent dip . Beyond more barriers and security guards, retailers aim to tilt the battle in their favor, replacing current security systems with smart and AI-powered systems. These improve on traditional models by being able to differentiate between suspicious and normal behavior. They can identify repeat offenders through facial ID, and other methods since many thieves wear hoods or masks, such as their clothing or walking gait. In grocery stores, AI is already used at self-checkouts in Walmart to monitor people “fake-scanning” high value goods and trying to escape without paying. Linked camera systems can follow and link criminals to their vehicles through license plate recognition. And in the integrated Internet of Things smart systems of the near future, they could track them through related big data services, identifying their mobile devices as they move, or even social media posts (not all criminals are particularly smart, after all). The question of privacy remains an obvious concern for shoppers. And, despite the recent state political opposition toward AI safety legislation, AI-powered security cameras are being rolled out around San Francisco stores today to save their stores for tomorrow. For those facing crime today, AI security systems and cameras help reduce the workload on the operators, alerting them to suspicious activity automatically. That means security teams can spend more time on the floor, being guided to incidents by the AI. Artificial intelligence can also perform behavior analysis that identifies and tracks suspicious activity, such as people loitering in one part of a store, or unusual movements like an accomplice trying to divert staff attention so the criminal can act unseen. Additional benefits of AI include the camera’s ability to identify the sound of breaking glass or gunshots and alert security teams and staff to the safest course of action, and call the police automatically. Beyond crime, an additional benefit of AI is footfall monitoring tools that can identify choke points or empty zones in the store, helping improve layouts for security, safety, and to improve sales. While the cost of a new AI security system for a large store can be substantial, the cost can be offset by lower insurance premiums, reduced crime, improved recovery rates, and greater visitor numbers as the store becomes a safer place. While crime continues largely unabated all shoppers are used to seeing cameras and their faces on screens by the tills. For stores, large and small, the arrival of AI comes as an invisible addition, but one that can improve their chances of survival and help drive growth through a range of AI-powered services. As mentioned at the start of this piece, shoplifting is a global problem, but retailers around the world are already seeing the benefits of AI in action. Across California and the wider US, Sam’s Club is installing AI-powered cameras in a trial to prevent shoplifting. It checks photos of their basket or cart against what they paid for at the checkout. British retail chain Co-op is using it in multiple stores to detect if someone has left without paying for an item, or whether someone has entered with a concealed weapon. And closer to home, a Chicago store reported a 50% drop in theft after installing AI-powered security cameras that monitor people making attempts to pocket or conceal items before leaving the store without paying. Given the distressed state of many malls, strip malls, and even high-end outlets, AI, already used successfully in medicine, insurance and many other areas of our lives is coming to a store near you to help prevent crime and keep the store alive, something that most shoppers will welcome. *The San Francisco Examiner newsroom and editorial were not involved in the creation of this content.
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